This brief summarizes key characteristics of programs funded through the Personal Responsibility Education Program (PREP) that primarily served highly vulnerable populations. Programs that “primarily served” a highly vulnerable population are defined as those that reported at least half of the youth they served were from one or more of the following populations: youth in foster care; youth in adjudication systems; homeless or runaway youth; pregnant or parenting youth; lesbian, gay, bisexual, transgender, and questioning (LGBTQ) youth; youth in residential treatment for mental health issues; and youth who have trouble speaking or understanding English. The research questions addressed in the brief include:

1. Where are programs that primarily served highly vulnerable populations implemented?
2. What are demographic and behavioral characteristics of youth in programs that primarily served highly vulnerable populations?
3. What are the sexual intention outcomes of youth in programs that primarily served highly vulnerable populations?