In 2019, an estimated 7.39 million people in the United States were living with IDD (Larson et al., 2022). Youth with mild to moderate IDD are just as likely to be sexually active as are their peers who do not have disabilities; however, they are less likely to receive comprehensive sexual education and less likely to report using condoms or prescription contraception at their last sexual encounter. This guide is designed to provide Adolescent Pregnancy Prevention (APP Program facilitators and other sexual health educators information and resources to advance equity for youth with intellectual and developmental disabilities (IDD) via delivery of high-quality sexual and reproductive health education and support services. The guide defines and provides an overview of IDD, describes potential barriers to delivering sexual and reproductive health education to students with IDD, provides facilitation tips and tools for working with youth with IDD, and offers additional resources to increase equitable and inclusive services for youth with IDD.