The U.S. Opioid crisis is affecting youth of all backgrounds and is not limited to youth of a specific socioeconomic status, race, gender, or geographic location, although it has affected some adolescent demographic groups more than others. This resource guide provides an overview of opioid use, impacts of and factors driving use, treatments for opioid use disorder and overdose, and tips and resources to help youth-serving professionals address adolescent opioid use.